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<B>Longitudinal Trajectory of a Cognitive Composite Score in Normal Cognition and
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   Lead Investigator:    Mike Malek-Ahmadi
   Institution      :    Banner Alzheimer's Institute
   E-Mail           :    michael.ahmadi@bannerhealth.com
   Proposal ID      :    584
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   Proposal Description:
   <textarea name="description" rows="12" cols="85" wrap="virtual" readonly>1. The primary goal of this study is to characterize the trajectory of a          cognitive composite score among cognitively normal individuals who remain         stable over time and with those who convert to amnestic mild cognitive            impairment. In addition, we will stratify the group APOE e4 carrier status        (homozygote, heterozygote, non-carrier). These analyses will be used to           determine the inclusion criteria and sample size for an Alzheimer's disease       prevention trial.                                                                                                                                                   2. We will be determining the optimal age range to enroll individuals in AD       prevention trials based on their APOE e4 carrier status by examining the          trajectory of decline in a cognitive composite score. This information is         essential to the execution of an AD prevention trial and could eventually serve                                                                                  as a methodological model for other AD prevention trials to use. </textarea>